Chloride – The Underrated Ion in Nociceptors
نویسندگان
چکیده
منابع مشابه
Voltage-gated ion channels in nociceptors: modulation by cGMP.
In tissue or nerve injury, proinflammatory mediators are released that can modulate a variety of ion channels found in nociceptors. The changes in channel activity, which primarily occurs through changes in intracellular pathways, may lead to the pathological states of hyperalgesia and allodynia. To understand further the regulatory mechanisms underlying the changes in channel activity, we used...
متن کاملSensitisation of Nociceptors – What are Ion Channels Doing?
Nociceptors are peripheral sensory neurones which respond to painful (noxious) stimuli. The terminals of nociceptors, which have a high threshold to stimulation in their native state, undergo a process known as sensitisation, or lowering of threshold, following injury or inflammation. Amongst sensory receptors, sensitisation is a property unique to nociceptors. A shift in the stimulus-response ...
متن کاملLocalization of Hydrogen Ion and Chloride Ion Fluxes in Nitella
Alternating bands of acid and base formation have been detected along the length of the internodal cell of Nitella clavata when it is illuminated, while in the dark this phenomenon is minimal. Chloride influx occurs only or largely in the acid-extruding regions, and this is also a light-dependent ion movement. Chloride efflux is slightly dependent on illumination and is not localized as are H(+...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2020
ISSN: 1662-453X
DOI: 10.3389/fnins.2020.00287